In a similar approach, novel multifunctional polymeric CAs were synthesized by conjugating polylactic acid/PEG (PLA/PEG)-P(Lys)/poly(lactic acid) (PLA) with anti-vascular endothelial growth factor (VEGF) antibody and Gd-DTPA yielding Anti-VEGF-PLA-PEG-PLL-Gd-NPs) for the targeted delivery of Gd-DTPA to the liver cancer. This evidence concerns the gene VEGFA and liver cancer.