These include the rapid cell division of cancer cells, an impaired ability to recognize and repair DNA damage that eventually leads to cell death by mitotic catastrophe or apoptosis, an overexpression of high mobility group (HMG) protein complexes in cancer cells, as well as the level and longevity of reactive oxygen species (ROS) generated in cancer cells after exposure to platinum drugs that could trigger a specific signaling transduction pathway and subsequently the activation of P38MAPK and JNK factors that mediate apoptosis [39]. Here, MAPK8 is linked to cancer.