CXCL10 and COVID-19: However, the cytokine/chemokine pattern most characteristic of COVID-19, i.e., TNFα, IL-1, IL-6, IL-12, MCP-1, CXCL10, represents—at least in the acute stages—a typical M1–Th1 pattern [110], which may be accompanied by partial M2–Th2 responses (i.e., IL-10) during later phases [111] as a reactive repolarization of macrophages over the time course of inflammatory reactions [100].