Excessive NF-κB activation and exuberant inflammatory responses with the involvement of endothelial cells, epithelial cells, and immune cells lead to further disturbances in other integrated systems, including the complement system, coagulation, and bradykinin systems, and feeding back into positive signaling feedback loops, accelerating COVID-19-associated inflammatory processes [43,44,45,46,47,48]. This evidence concerns the gene NFKB1 and COVID-19.