From the present perspective, we hypothesize that the global expression pattern of the Duffy antigen receptor for chemokines (DARC), with a high frequency in the Duffy-negative population, particularly in the subtropical regions of Africa, as a result of the high selection pressure brought on by Plasmodium vivax could be one of the factors contributing to the lower COVID-19 incidence in Africa. This evidence concerns the gene ACKR1 and COVID-19.