From the present perspective, we address immunological mechanisms and their correlation with specifics of Africa’s population, genetic factors, pre-existing immune status, racial differences in cytokine induction patterns, high helminth infection rates in tropical regions, and specific factors related to malaria endemic to the sub-Saharan area, such as differences in Duffy antigen expression (DARC, Duffy antigen receptor of chemokines) and continent-specific coverage of various medications related to helminth infection and malaria. Here, ACKR1 is linked to malaria.