Cytokine storm, hyperinflammation, multiorgan failure, and acute respiratory distress syndrome were described in COVID-19 patients with high fever, dyspnea, lymphopenia, and high serum ferritin, D-dimers, C-reactive protein (CRP), and cytokines, including IL-1b, IL-6, and TNF-α [31,32]. The gene discussed is IL1B; the disease is COVID-19.