PDC and infection: While these results are in line with a role for pDC differentiation into tDC/cDC2 as a mechanism for reduced pDC numbers during infection, further work will be necessary to definitively show whether the transition between pDC and cDC2 like cells, that was first reported during in vivo viral infection [139,140], uses tDC as an intermediate, and whether disrupting this phenomenon can restore pDC numbers.