The dengue patients with mucosal bleeding (n = 22) presented significantly increased plasma levels of IL-6 (median: 20 pg/mL; IQR: 11.4–38.8; p = 0.005) and IL-10 (median: 4.1 pg/mL; IQR: 2.7–11.8; p = 0.028) compared to those without mucosal bleeding. Here, IL6 is linked to dengue disease.