The results of our study demonstrated two novel associations between the SNPs of IL28B and IlB1 and the neonatal neuroimaging results in cCMV: IL1B polymorphism was associated with the reduced risk of ventriculomegaly, while IL28B polymorphism significantly increased the risk of ventriculomegaly on MRI and cystic lesions on US and MRI. Here, IL1B is linked to Ventriculomegaly.