Higher expression of immunosuppressive cytokines capable of pro-tumoral reprogramming (Il10, Il6), immune checkpoint (B7-H3), hypoxia-related and non-related factors that promote tumor proliferation and metastasis (Hif1a, Kitl, Igf1, ptgs2), and pro-angiogenic factors (Cxcl5, Hif1a) were also detected. The gene discussed is HIF1A; the disease is neoplasm.