IFNG and neoplasm: IL-12 is a heterodimeric master regulator of the immune system, primarily responsible for cell-mediated immunity, with diverse functional effects, including growth/activity of NK, T, and B cells; differentiation of Th1 cells; reprogramming immune suppressive cells (MDSCs, TAMs); stimulating the production of IFNγ; enhancing MHC I antigen presentation in tumor cells; and anti-angiogenesis [151,158].