CD274 and neoplasm: oHSV2 (Figure 4) expressing anti-human anti-PD-1 mAb (oHSV2-aPD1) was examined in B16R cells (B16 expressing HSV receptor HVEM) in syngeneic mice expressing human PD-L1, where it significantly inhibited tumor growth, but not survival, compared to oHSV2 [40].