On the contrary, significantly higher expression of the ISG genes, DDX58 (RIG-I), CXCL10 and IL-6 genes was observed in positive SARS-CoV-2 samples at baseline compared to negative subjects (Figure 2B), albeit ISG expression decreased at follow-up 3 days later, suggesting that viral infection is inducing an IFN-mediated antiviral response that is rapidly counteracted by viral proteins. This evidence concerns the gene RIGI and viral infectious disease.