Given the recognized crucial functions of BID, BIM, PUMA, and BOK in activating BAX/BAK-dependent cell death, we assessed viability and viral titer in WT compared to Bid−/−Bim−/−Puma−/− as well as Bid−/−, Bim−/−, Puma−/−, and Bok−/− BMDM during infection with K!81 or ∆M38.5/M41.1 viruses (Figure 2F left panel and Figure S2B–E). This evidence concerns the gene BAK1 and infection.