Histopathological evidence suggests the presence of hypertrophied cardiomyocytes along with inflammatory infiltrates, focal edema, interstitial hyperplasia, fibrosis, degeneration, necrosis and signs of lymphocytic myocarditis, the presence of CD4 T-cells along with other inflammatory infiltrates in myocardium, endocarditis and inflammation of interstitial tissue, damaged cell membrane interstitial cells, and leukocyte infiltration in humans with SARS-CoV-2 infection [48,64,81,82,83,84,98,99,100,101]. This evidence concerns the gene CD4 and endocarditis.