Here, we confirmed R-613 specificity for EGFRvIII receptor by using a syngeneic murine glioblastoma model (HGG-E), induced by transplanting INK4a−/− neural progenitor cells overexpressing EGFRvIII in the striatum of BALB/c mice [54]. The gene discussed is CDKN2A; the disease is glioblastoma.