RPS23 and glioblastoma: Most of them were engineered with deletion in both copies of the γ134.5 neurovirulence gene and possibly additional deletions [6]: oHSV G207, lacking the two copies of γ134.5 and UL39 genes, showed an increased glioblastoma selectivity, and oHSV G47Δ, with an additional deletion in US12, had an increased viral replication in glioblastoma cells [27,28].