In other recombinant oHSVs, to complement γ134.5 deletion and maintain glioblastoma specificity, heterologous genes as the human GADD34 gene (for oHSV NG34) or the IRS1 gene from cytomegalovirus (for oHSV C134) were engineered into the viral genome under the control of the nestin promoter [30,31]. This evidence concerns the gene NES and glioblastoma.