RNASE2 and allergic disease: Eosinophils are leukocytes involved in allergic diseases and host protection against parasites through the release of cytokines/chemokines, mediators, antimicrobial peptides, eosinophil extracellular traps (EETs), and cytotoxic granule cationic proteins, such as major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN) (7–9).