UMOD and infection: Consistent with the result shown in Figure 1A, IFN-β mRNA induction in response to IAV or VSV infection was suppressed by treatment with THGP in a dose-dependent manner (Figure 2A,B), while THGP did not affect IFN-β mRNA induction in response to infection with EMCV, which is recognized by MDA5 and does not produces triphosphate RNA [5] (Figure 2C).