RIGI and phenotype: The superkiller viralicidic activity 2-like (SKIV2L) RNA helicase, one of causative genes for tricho-hepato-enteric syndrome (THES), also known as syndromic diarrhea (SD) or phenotypic diarrhea (PD), is known to be involved in the formation of an RNA exosome that inhibits ER stress, such as the thapsigargin-induced RIG-I signaling pathway [37].