Contrastingly, it has also been reported that expression of ACE2 is the highest in young women and children; the lowest in people suffering from chronic disease, such as sugar, obesity, and high blood pressure; and it declines with age, which links the ACE2 expression inversely with risk of unfavorable outcomes after severe presentation of disease [33,134]. This evidence concerns the gene ACE2 and obesity due to melanocortin 4 receptor deficiency.