ACE2 and COVID-19: On the other hand, blocking of ADAM-17 mediated Angiotensin converting enzyme 2 (ACE2) shedding and upregulation of ACE2-Angiotensin-1-7-MasR axis of Renin Angiotensin System (RAS) (see Figure 1 for detailed information regarding this pathway) have been found to mediate enhanced COVID-19 severity in males [8].