Besides multi-organ failure in the heart, liver and kidneys, hyper-ferritinemia, and coagulopathy, usually presented with higher level of blood urea nitrogen (BUN), D-dimer, C-reactive protein (CRP), and Creatine (Cr) are characteristic of not only MAS, but also of secondary Hemophagocytic lymphohistiocytosis (sHLH) [4]. The gene discussed is CRP; the disease is macrophage activation syndrome.