- frequent co-infection by multiple, geneticallydistinct S. aureus strains often differing in antibiotic susceptibility- identification of common set of S. aureusgenes frequently mutated during long-term adaptation (rpoB,fmtB, agrA, rpsJ, rsbU, thyA,set9, walK, ebh)- contribution to antimicrobial resistance (rpsJ) and bacterial persistence (agrA, rsbU, ebh) or both (rpoB,thyA) - open pangenome with incoming new genes. Here, SETD7 is linked to coinfection.