Tritrichomonas colonization in mice with constitutive activation of the tuft-ILC2 circuit, due to uninhibited IL-25 activation of ILC2s (A20fl/fl), confers a measure of protection against infection with the helminths H. polygyrus and N. brasiliensis, as measured by reduced worm fecundity and worm burdens which was abrogated in tuft cell-deficient mice [23]. This evidence concerns the gene IL25 and infection.