ERVW-1 and type 1 diabetes mellitus: The hypothesis that MAP may be involved in HERV-W transactivation is also supported by the presence of highly expressed CD68+ in granulomatous lesions of infected goats, indicating high lysosome counts and acid phosphatase activity [41], similarly, increased expression of CD68+ infiltrating macrophages has been reported in the pancreas of T1D patients, in this case linked to HERV-W expression [22].