Infection of monocytes by VSV has been reported to suppress type I IFN and cytokine (IL-27 and TNF) responses in a viral RNA-specific and TLR7-dependent pathway [93], and TLR7−/− mice show significantly reduced VSV titers in the draining lymph nodes and diminished viral replication in subcapsular sinus macrophages [94]. Here, TLR7 is linked to infection.