For example, in LMP1-positive NPC tissues of elderly individuals, the expression of the EGFR was closely related to the high enrichment of p53 in the nucleus and the expression of Bcl-2, suggesting that the up-regulation of the EGFR or Bcl-2 was associated with a poor prognosis and resistance to chemotherapy-induced apoptosis [74]. Here, TP53 is linked to nasopharyngeal carcinoma.