LMP1 contributes to the development and progression of NPC by many mechanisms, including the regulation of the expression and phosphorylation of the transcription factor p53 [21], the EGFR and the STAT3 activation allowance [22], as well as necroptosis inhibition through the RIP3 promoter hypermethylation [23]. Here, STAT3 is linked to nasopharyngeal carcinoma.