Fritsche LG et al. have analyzed many genes association with AMD and found that several genes, which are involved in the generation and remodelling of high-density lipoproteins (HDLs), namely ATP-binding cassette transporter A1 (ABCA1), apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP), and hepatic lipase C (LIPC), are also linked to AMD [30]. Here, APOE is linked to age-related macular degeneration.