The level of granulysin expressed in blister fluid in cytotoxic T cell-mediated disorders, including SJS/TEN and both generalized and localized bullous FDE, has been found to be significantly higher than in non-cytotoxic T cell-mediated blistering disorders such as bullous lupus erythematosus, pemphigus vulgaris, and bullous pemphigoid [49]. Here, GNLY is linked to toxic epidermal necrolysis.