The principal words we included in the search were “severe sepsis” OR “sepsis”, OR “septic shock”, AND “procalcitonin”, AND/OR “pro-adrenomedullin”, OR “MR-proADM”, AND/OR “IL-6”, AND/OR “systemic inflammation”, AND/OR “organ failure”, AND/OR “infections”, AND “diagnostic biomarkers” AND “prognostic biomarkers”, OR “bacteria-induced sepsis”, AND/OR Emergency Department (ED) OR Emergency Medicine. This evidence concerns the gene ADM and Sepsis.