The AUC was 0.92 (95% CI: 0.89–0.96, p <0.001) for insulin use at DM onset, 0.92 (95% CI: 0.88–0.97, p < 0.001 for one year after DM diagnosis, and 0.92 (95% CI: 0.87–0.98, p < 0.001) for two years after DM diagnosis. The gene discussed is INS; the disease is diabetes mellitus.