MTDH and neoplasm: Higher metadherin mRNA relative expression levels were significantly related to the tumor number > 2 (mean 8.6 ± 2.3, range 3.2–10.3, p-value = 0.001), larger tumors > 5 cm (mean 8.3 ± 1.4, range 5.2–10.3, p-value < 0.001), positive nodal metastasis (mean 8.3 ± 1.7, range 5.7–10.3, p-value = 0.003), distant metastasis (mean 8.3 ± 1.7, range 5.7–10.3, p-value = 0.003), vascular invasion (mean 7.4 ± 1.6, range 5.1–10.3, p-value < 0.001), and stage C (mean 9.1 ± 0.9, range 8.0–10.3, p-value = 0.004) (Table 4).