In 2020, Matyas et al. demonstrated that a selective CB2 agonist (HU910) prevented cardiac and renal tissue damage in BDL mice, indicating that CB2 has a pivotal pathophysiological role in hepatic cardiomyopathy, and CB2-specific agonists may delay or prevent the development of cardiomyopathy or renopathy associated with severe liver disease [100]. Here, CNR2 is linked to liver disorder.