Building on the role of lipid profile in atherosclerosis, some studies demonstrated that CBD and Δ9-THC inhibit 15-lipoxygenases, an enzyme group responsible for oxLDL and 13-hydroxyoctadecadienoic acid (13-HODE) formation, both major causal factors connected to atherosclerosis and potentially other CVDs [64,70]. Here, ALOX15B is linked to atherosclerosis.