In addition, STAT3 can be upregulated by Janus-activated kinase 2 (JAK 2), toll-like receptor 4 (TLR 4), human epidermal growth factor receptor (EGFR), IL-6-type family, and several G protein-coupled receptors (GPCRs), which significantly associates development of resistance in various cancers [15,16,17]. The gene discussed is STAT3; the disease is cancer.