TNF and psoriasis: The influence of polymorphisms of TLR2 (rs4696480 and rs11938228), TLR5 (rs5744174), and TLR9 (rs352139) on treatment response has been demonstrated in Caucasian patients (from Denmark) diagnosed with moderate-to-severe psoriasis and treated with anti-TNF drugs (n = 376) and with UTK (n = 230) [95].