The TNF-308 (rs1800629), TNF-238 (rs361525), and TNF-857 (rs1799724) variants have been associated with the risk of suffering from psoriasis and with the response to anti-TNFs in psoriasis and other autoimmune diseases, such as ankylosing spondylitis and Crohn’s disease [79,90,91]. The gene discussed is TNF; the disease is ankylosing spondylitis.