We first examined the expression of BRM and BRG1 subunits in the REMBRANDT database of normal tissue and GBM tumor samples and found that, while BRG1 expression in GBM was higher than in non-tumor tissue, BRM expression was lower in GBM tumor tissue as compared to non-tumor samples (Figure 1A). The gene discussed is SMARCA4; the disease is glioblastoma.