Transient transfection of the IRF-1 dependent reporter construct in these BRG1KO cells nearly completely ablated the combined effect of PFI-3 and IFN as compared to parental wild-type GBM cells (Figure 5B), which strongly suggested that the effect of PFI-3 was highly dependent on the BRG1 subunit of SWI/SNF. The gene discussed is SMARCA4; the disease is glioblastoma.