As was the case with the CVD drugs, persons with diabetes have a 2–3 (for gabapentin 4 times) higher prevalence of use of analgesics including opioids, psycholeptics and psychoanaleptics compared to the general population and essentially follow the same order of prevalence of use as seen for CVD; T2D taking insulin > T2D taking no insulin > T1D. The gene discussed is INS; the disease is type 2 diabetes mellitus.