Ten acridones isolated from Atalantia monophylla, namely N-methylatalaphylline, atalaphylline, N-methylatalaphyllinine, atalaphyllinine, N-methylcycloatalaphylline A, citrusinine I, citrusinine II, glycosparvarine, citruscridone, and buxifoliadine C, were filtered for their drug-likeness properties and evaluated for their activities in three AD pathogenesis-associated mechanisms including antioxidant activity, AChE inhibition, and prevention of beta-amyloid (Aβ) aggregation. The gene discussed is ACHE; the disease is Alzheimer disease.