EGFR and non-small cell lung carcinoma: For instance, in the phase III MARIPOSA trial (NCT04487080), patients with locally-advanced or metastatic NSCLC harboring EGFR mutations (exon 19 deletion or L858R mutation) are randomized to receive either the combination of amivantamab and lazertinib, lazertinib alone or the standard of care (SoC) osimertinib alone as first-line therapy [48].