Preliminary analysis on advanced NRG1-fusion positive cancer patients (10 pancreatic, 18 NSCLC, 5 other tumors) showed a manageable safety profile and an ORR of 27% (90% CI, 15–43%), with an encouraging ORR of 40% (4/10; 90% CI, 15–70) in patients with pancreatic cancer [62]. Here, NRG1 is linked to non-small cell lung carcinoma.