MDM2 and glioblastoma: Firstly, it may be suggested that a prominent role of this integrin will be found in mesenchymal GBM inasmuch as probes of a correlation between mRNA and protein levels will be given in this subclass of tumors; secondly, extrapolation from our preclinical results on the negative relationships between the integrin and p53 signaling may indicate that blocking the integrin in a p53 WT background in addition with reactivation of p53 signaling (as for example with mdm2 inhibitors) will be more effective [17,36].