In addition, amygdalin alters cell cycle progression in bladder cancer cells by down-modulating cyclin-dependent kinase 2 (CDK2) and cyclin A. Amygdalin-induced suppression of CDK2, a key regulator of G1-S transition and modulation of G2 progression, induces cycle arrest in G0/G1 phase, thus inhibits cell proliferation and growth [41]. Here, CDK2 is linked to urinary bladder cancer.