The works herein reviewed suggest that, under certain circumstances, it is possible to induce apoptosis in cancer cells by activating the Wnt/β-catenin signaling pathway and/or receptors with tyrosine kinase activity that leads to β-catenin stabilization, either by deactivating the degradation complex, α-catenin, or the Notch signaling pathway, or by activating the Hippo pathway, which in turn inactivates the YAP/TAZ transcriptional factors. This evidence concerns the gene TAFAZZIN and cancer.