It has also been reported that an activation of the Wnt/β-catenin signaling in WNT3-conditioned medium increased apoptotic cell death rates promoted by the recombinant human TNF receptor death-inducing ligand (rhTRAIL) in melanoma cells, by increasing the levels of the Bim and PUMA proapoptotic proteins, reducing the levels of the Mcl1 antiapoptotic protein, and upregulating mRNA expression for genes like axin2, LEF1, and TNFRSF19 [203]. The gene discussed is AXIN2; the disease is melanoma.