CCN2 and non-small cell lung carcinoma: Mst1 overexpression has also been reported to decrease cell viability and induce apoptotic cell death in the human non-small cell lung cancer (NSCLC) A549 line both in vitro and in vivo, by promoting the cytosolic relocation and Ser127 phosphorylation of YAP, as well as inducing a decrease in amphiregulin, the connective tissue growth factor, and Survivin mRNA [255].