An activation of Wnt/β-catenin signaling in B16-F1 melanoma cells due either to a lentivirus-led expression of WNT3A (B16:WNT3A) and/or pharmacological GSK-3β inhibition results in significantly reduced proliferation rates with respect to B16:GFP cells, along with an upregulation of axin2 [190]. This evidence concerns the gene AXIN2 and melanoma.