Biechele et al. showed that an activation of the Wnt/β-catenin pathway and PLX4720 synergistically induced apoptotic cell death in BRAFV600E mutant melanoma cell lines by increasing the activity of the proapoptotic isoforms BimL and BimS, as well as caspase-3 [193]. This evidence concerns the gene BCL2L11 and melanoma.