Inhibiting MITF with siRNA in melanoma cells induced a strong increase in the invasive activity in 3D collagen, suggesting that MITF suppresses the invasive capacity of β-catenin by blocking the rho-associated kinase (ROCK)-regulated cell morphology in invading WM266-4 melanoma cells, while interfering with β-catenin-induced expression of MT1-MMP, which activated proMMP-2 [208]. The gene discussed is MITF; the disease is melanoma.