MST1 and hepatocellular carcinoma: Kim et al. demonstrated that the loss of the Hippo kinases Mst1/2 in hepatocytes induces the activation of Notch signaling and establishes a positive feedback loop with the Yes-associated protein/WW domain containing the transcription regulator 1 (YAP/TAZ), which rapidly results in hepatomegaly and hepatocellular cancer [240,241].