PCNA and central nervous system cancer: Tan et al. reported that the dapper homolog 2 (DACT2), a tumor suppressor, is under-expressed in glioma tissues, and its expression was negatively correlated with glioma grade and a poorer survival, while its overexpression in U87 and U251 glioma cells induced arrest of the cell cycle in the G0/G1 phase, reducing cell proliferation and promoting apoptosis through a downregulation of PCNA and cyclin D1, while increasing the levels of the proapoptotic protein Bax and the pYAP transcription factor [125].