TP53 and medulloblastoma: In addition, Salaroli et al. showed that radiation triggers Wnt/β-catenin pathway activation with the ensuing cell cycle arrest and apoptotic cell death in medulloblastoma DAOY (p53-mutated) and D283MED (wild-type p53) cell lines; apoptosis and growth arrest in TP53-mutated medulloblastoma cells could be mediated by Wnt/β-catenin, bypassing the p53 pathway [234].