TAFAZZIN and neoplasm: The binding of Jag1 to Notch receptors results in the proteolytic cleavage of receptors by the γ-secretase complex and proteins of the ADAM family, to expose the Notch intracellular domain (NICD), which increases the activity of TAZ by blocking its binding to the E3 ubiquitin ligase β-TrCP; this induces a rapid tumor initiation and progression in hepatocytes with a Hippo signaling inactivation.