Finally, immunofluorescence staining performed by using anti-CD31, -αSMA, -VEGF, -MMP-2 and -MMP-9 antibodies demonstrated a significant reduction of tumor angiogenesis and capability of tumor invasion, when HPR was administered through NL-HPR and, at a greater extent, through NGR-NL-HPR [80]. The gene discussed is MMP2; the disease is neoplasm.