ANXA5 and neoplasm: Additionally, PC3 and A549 cells as well as HEK293T cells, as non-tumor epithelial cells, were treated with LPS, doxycycline and LPS-doxycycline combinations, as described in Figure 1B and Figure S1, to determine the impact on cell viability and the nature of the cell death induced (pyroptosis or apoptosis) by Annexin V assay.