Abnormal alpha-synuclein (α-syn) depositions (α-synucleinopathies) in neurons, nerve fibers, or glia cells are the hallmark for many neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) [1]. The gene discussed is SNCA; the disease is Parkinson disease.