MSLN and pachyonychia congenita: For the functional test of our FcBP-LGA-PEI copolymer, we loaded a human anti-EGFR Ab (Cetuximab) as a model system because we demonstrated that MSLN increased EGFR expression in PC cell lines (Figure 3A) and Cetuximab can significantly inhibit cell proliferation in a subset of PC cell lines with high expression of both MSLN and EGFR [53].