The mouse treated with MSLN scFv-LGA-PEI/miR-198 mimics NPs showed an enhanced red fluorescence in the Mia-MSLN tumors compared with the mouse treated with LGA-PEI/miR-198 mimics NPs, suggesting that MSLN scFv-LGA-PEI polymer more efficiently delivers RNA into the pancreatic tumors with high expression of MSLN (Figure 7C). Here, GLS2 is linked to pancreatic neoplasm.