Although EGFR gene amplifications and mutations in PC are rare [91,92], the overexpression of EGFR is observed in 9–90% of PC tissues [93,94,95] and it has been associated with higher-stage and more aggressive tumors, worse clinical outcomes, poor survival, and metastasis of PC [53,96,97]. The gene discussed is EGFR; the disease is pachyonychia congenita.