LRP1B and Familial prostate cancer: Moreover, epigenetic mechanisms are known to affect LRP1B expression in several cancers; these include hypermethylation of CpG island located in the LRP1B promoter region [62,64,68,70,78,97,98,99,100], histone deacetylation of the LRP1B promoter region [78], and microRNA (miRNA)-mediated post-transcriptional regulation such as miR-548a-5p [thyroid cancer [62], miR-500 and miR-301b-3p, and prostate cancer [101,102].