On the other hand, LRP1B-silencing with small interfering or short hairpin RNAs (siRNAs or shRNA, respectively) resulted in: (i) increased anchorage-independent growth, cell migration, and invasion in renal cancer cell lines [78], (ii) enhanced cell proliferation in lung cancer cell lines [21], and (iii) promoted anchorage-independent growth, cell proliferation, and migration in colon cancer cell lines [106]. The gene discussed is LRP1B; the disease is malignant colon neoplasm.