Moreover, the restoration of LRP1B expression with the mini-receptor: (i) reduced cell proliferation in gastric cancer cell lines and tumorigenicity in nude mice [100]; (ii) suppressed cell proliferation in ovarian cancer cell lines [59,60]; (iii) inhibited cell proliferation and migration in colon cancer cell lines [106], and (iv) decreased in vivo tumor development and growth, impaired cell invasion, and modulated thyroid cancer cells’ secretome [62]. This evidence concerns the gene LRP1B and malignant colon neoplasm.