Through the re-establishment of LRP1B expression (with mini-receptor) in LRP1B-deficient cancer cells, it was observed the suppression of anchorage-dependent growth (in esophageal [68] and gastric cancer cells [100]) and anchorage-independent growth (brain [57], gastric [100], thyroid [62] and colon cancer cells [106]). The gene discussed is LRP1B; the disease is malignant colon neoplasm.