LRP1B and melanoma: Recently, based on data from “The Cancer Genome Atlas TCGA” available on the cBioPortal database, Brown et al. showed that LRP1B somatic alterations were identified in approximately 12% across all samples and in more than 20% in multiples tumor types including NSCLC, melanoma, esophageal, stomach, head and neck, uterine, and bladder cancers [58].