Future studies should focus on the reasons why some patients are “responders” and some “non-responders” to devices switch and explain the relative loss of long-term efficacy on the hyperglycemia metrics, especially in relationship with insulin resistance and via the management of alarms thresholds as much as possible it can be in a real-life context (alarms weariness, regular reassessment of thresholds, corrective behaviours if alarms are triggered). The gene discussed is INS; the disease is Hyperglycemia.