One possible explanation is that suppression of moesin expression may cause the production and/or release of pro-inflammatory cytokines such as IFN-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, all of which are key factors in augmenting PD-L1 expression at transcriptional level in the tumor region [17]. The gene discussed is CD274; the disease is neoplasm.