PGP and cancer: In fact, a growing body of evidence suggests that ERM proteins post-translationally regulate the plasma membrane localization and functional activity of some drug transporters, including P-glycoprotein (P-gp), multidrug resistant protein (MRP)-2, and MRP-3 [33,34,35,36], as well as certain cancer-related proteins, such as epidermal growth factor receptor (EGFR) 2, several receptor kinases, and cluster of differentiation (CD) 20 [37,38,39] through the direct molecular interaction.