RB1 and hepatocellular carcinoma: Evidence has been accumulating in recent years about the important role that PSMD10 plays in hepatocellular carcinoma, for instance it has been shown to prevent the degradation of Octamer-binding transcription factor 4 (Oct4), regulates Retinoblastoma 1 (Rb1), tumor protein 53 (Tp53) and cisplatin sensitivity.