PirH2 (p53-induced protein with a RING-H2 domain) is an E3 ligase that has not been fully structurally characterized, and that presents a tissue-dependent role in the regulation of tumoral processes, as it is shown to be overexpressed in different types of cancers, such as lung and prostate cancer, but it is under expressed in other types of cancers such as breast and ovarian cancer [100]. The gene discussed is RCHY1; the disease is cancer.