Cell lines resistant to 5-fluorouracil (5-FU) (SUN-C5/5FU-R), IRT (SUN-C5/IRT-R) and OXT (SUN-C5/OXT-R) were isolated from the wild-type colon cancer cell line (SUN-C5/WT), and BA alone was effective against wild type, 5FU-R and OXT-R. This evidence concerns the gene OXTR and malignant colon neoplasm.