Though synthetic cholinesterase inhibitors, including rivastigmine, donepezil, and galantamine are usually employed as a remedy to AD, there is a growing interest in the search for new cholinesterase inhibitors from natural sources due to the drawbacks of synthetic ones, and most non-alkaloid natural anticholinesterase compounds are terpenoids, phenolic compounds, and coumarins, amongst others. The gene discussed is BCHE; the disease is Alzheimer disease.