For this reason, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors such as galantamine, donepezil, and rivastigmine are used in the management of AD, and the inhibition of the two types of cholinesterase enzymes (AChE and BuChE) as remedial for such treatment [10]. The gene discussed is ACHE; the disease is Alzheimer disease.