BAK1 and cancer: Since (−)-6-epi-artemisinin (2) selectively induces apoptosis by acting solely to cancer cells, as demonstrated by the killing of epithelial cancer cells W2 but not normal Human Mammary Epithelial Cells (HMEC), (−)-6-epi-artemisinin (2) induces apoptosis upstream of Bax and Bak, and it may have potential for use as an antiproliferative agent that exploits the apoptosis pathway in tumor cells.