IL2 and type 1 diabetes mellitus: NOD.insulin-dependent diabetes (Idd)3/Idd5 mice, which have both protective alleles with the Idd3 locus (Il2) and the Idd5 locus (Ctla4, Slc11a1, and Acadl), were protected from T1D and possessed dramatic alterations of microbiota composition compared with wild-type mice [51,52].