It has been reported that an augmented number of intestinal Th17 cells and more severe arthritis in SKG mice receiving microbiota from patients with RA and elevated IL-17 cytokines in regional lymph nodes and the colon after treatment with the arthritis-related autoantigen 60S ribosomal protein L23a were found in an in vitro study [143]. The gene discussed is RPL23A; the disease is Arthritis.