CD8A and type 1 diabetes mellitus: Furthermore, the deficiency of MyD88 in NOD mice contributed to altered composition of intestinal microbiota and strongly m CD8+ T cell-mediated T1D development through gut microbiota in islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive CD8+ T cell receptor NY8.3 transgenic NOD mice [51,53].