AGT and cardiac hypertrophy: In addition, corroborated evidence from experimental studies conducted on both animal models and in patients has indicated Ang II involvement in the pathophysiology of cardiac hypertrophy and failure, a conclusion based on the following observations: (1) Ang-II is produced within the myocardium, (2) Ang-II is activated within the failing hypertrophic heart, and (3) the pharmacological inhibition of the RAS and Ang-II in animal models and in patients with a hypertrophic heart experiencing a myocardial failure showed to be highly efficacious [4].